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At the molecular level, upregulation of hypoxia-inducible factor-1 (HIF-1) has been observed in active MS plaques by immunohistochemistry [130, 131], and the upregulation of genes associated with ischemic preconditioning, including HIF-1, has been observed in NAWM in patients with MS [132]

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And then there is the hypothalamus, pituitary, thyroid axis and the hypothalamus, pituitary, gonadal axis that are responsible respectively for thyroid hormone and sex hormone production

Briefly, this study reported that GPx1-KO mice exhibited significantly higher surviving crypt cells than GPx2-KO mice and wild-type mice